Obito's mangekyo sharingan's irregular vision is most likely caused by hashirama's cells present in his body.
When Did Shisui Unlock His Sharingan : Shisui sees kakashi grabbing his neck start to look at kakashi's neck and he sees that there are three black magatamas on his neck.
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What Went Wrong With The Sharingan By Ray Valentine Medium - To unlock either variant, one would have to be exposed to a particularly shocking in itachi's case, he had achieved this when he firsthand witnessed the death of his friend, shisui uchiha.
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Shisui Uchiha Waterkai Naruto Fanon Wiki Fandom - Shisui unlocked his mangekyo sharingan during the 3rd shinobi war where his best friend got killed in front of him and the despair of not being able to save him when his best friend itachi made history by becoming the first uchiha anbu in history, shisui closely followed suit.
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Why Uchiha Itachi Didn T Make His Mangekyo Sharingan Eternal Anime Manga Stack Exchange - Shisui also succeeded in manifesting a red tomoe susanoo which owing to his talent, even without his eternal mangekyou sharingan, indra was capable of by implanting his brothers' eyes into his own, madara unlocked the eternal mangekyo sharingan.